Author's response to reviews Title: Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells Authors:

P-49: Effect of Crab Shell HydroalcoholicExtract Induced Apoptosis in ProstateCancer Cell Line

Background: Prostate cancer is the second most common cancer in men worldwide and the third most common cancer in Iranian men. Chemotherapy is used to treat this cancer, but it has toxic effect. Natural compounds found in marine organisms and plants have anticancer considered. The aim of the present study was to investigate the effect of crab shell extract on induction of apoptosis in prostate ...

Wild Type p53 Gene Transfer Increases Chemosensitivity and Apoptotic Response of PANC-1 Pancreatic Tumor Cell Line

The effect of p53 gene therapy on chemosensitivity and apoptotic response of PANC-1 tumor cells, which express high amount of mutant p53, to cancer chemotherapeutic agents of Etoposide and Doxorubicin was investigated. Comparison of the chemosensitivity of PANC-1 cells to its wild type p53 transfectants showed that wt-p53 expressing transfectants are more sensitive to both Etoposide and Doxorub...

Synergistic Effects of NDRG2 Overexpression and Radiotherapy on Cell Death of Human Prostate LNCaP Cells

Background: Radiation therapy is among the most conventional cancer therapeutic modalities with effective local tumor control. However, due to the development of radio-resistance, tumor recurrence and metastasis often occur following radiation therapy. In recent years, combination of radiotherapy and gene therapy has been suggested to overcome this problem. The aim of the current study was to e...

Author's response to reviews Title: Stable Alterations of CD44 Isoform Expression in Prostate Cancer Cells Decrease Invasion and Growth and Alter Ligand Binding and Chemosensitivity Authors:

Potent induction of phase 2 enzymes in human prostate cells by sulforaphane.

Two population-based, case-control studies have documented reduced risk of prostate cancer in men who consume cruciferous vegetables. Cruciferae contain high levels of the isothiocyanate sulforaphane. Sulforaphane is known to bolster the defenses of cells against carcinogens through up-regulation of enzymes of carcinogen defense (phase 2 enzymes). Prostate cancer is characterized by an early an...